Bile Acids Against Animal Intestinal Pathogens


Antimicrobial resistance is an emerging challenge to both agriculture and healthcare. Limiting antimicrobial usage in agriculture is one of the important steps to control antimicrobial resistance. However, antimicrobial free feeding regiments practiced around the world have precipitated outbreak of intestinal diseases (e.g. necrotic enteritis) and food borne diseases (e.g. campylobacteriosis). Campylobacter jejuni  is a poultry commensal microorganism but a food borne bacterial pathogen with increasing antibiotic resistance incidences. Cases of campylobacteriosis at millions ranked second among all food borne pathogens with limited treatment options and severe post-infectious complications.


Microbiota-metabolized bile acids delivered in feed, drinking water, or other routes improve animal productivity and prevent against prevalent food born bacterial pathogens such as Campylobacter jejuni colonization in chickens. The bile acids also reduce coccidiosis- and Clostridium perfringens induced necrotic enteritis and attenuate other animal intestinal pathogens. Altogether this invention will provide novel, effective and sustainable approaches for antimicrobial free feeding regiments in food animal production and animal health.



Patent Information:
App Type Country Serial No. Patent No. File Date Issued Date Expire Date
Provisional United States 62/520,724 6/16/2017    
Provisional United States 62/529,569 7/7/2017    
Animal Agriculture
For Information, Contact:
Bryan Renk
Associate Director for Technology Commercialization
University of Arkansas TCO
Xiaolun Sun
© 2019. All Rights Reserved. Powered by Inteum