Trans-,Trans- Conjugated Linoleic Acid Compositions and Use Thereof


Conjugated linoleic acid (CLA) is a mixture of positional and geometrical isomers of linoleic acid (LA) with conjugated double bonds. Biomedical studies and clinical trials have demonstrated that CLA has many health benefits such as: reduction of body fat, decreasing cancer risk and reduction of tumor proliferation, improved immune function, isomer specific diabetes prevention, and prevention of cardiovascular disease as well as anti-inflammatory properties.

CLA occurs naturally in dairy products and meat from ruminant animals, where they are synthesized from linoleic acid by rumen bacteria. However, dairy products contain only 6-8 mg CLA per gram of fat with fat typically comprising one third of the dairy food. Thus, a healthy diet may only contain about a gram of CLA, which is below the 3.2 grams’ threshold necessary to realize a clinical effect. Therefore, it would be desirable to develop CLA rich foods which are also low in saturated fat.

Our Inventors have developed a portfolio of technologies using conventional oil processing equipment to produce a 10 - 15% CLA rich oil from commercial linoleic acid rich oils.  The group of inventions encompasses the following titles:

- CLA-rich oil production with reduced ruthenium catalyst dose

- Conjugated Linoleic Acid rich vegetable oil production from linoleic rich oils by heterogeneous catalysis

- Sulfur-Enhanced Catalytic Production of CLA-Rich Vegetable Oil without Hydrogen Gas

- Trans, trans-conjugated acid composition and use thereof

These CLA-rich oils can be used in the following products:

1.       Food oils: Salad oil, fry oil, cooking oil, margarine and shortening.

2.       Feeding oil: CLA-rich oils can be used in animal and poultry feed to produce CLA­ rich meat, milk or eggs.

3.       Industry application: CLA-rich oil has dry oil characteristics, it could be used for coatings and polymer applications.


Patent Information:
App Type Country Serial No. Patent No. File Date Issued Date Expire Date
Non-Provisional United States 13/471,624 8,809,560 5/15/2012 8/19/2014 5/15/2032
For Information, Contact:
Bryan Renk
Associate Director for Technology Commercialization
University of Arkansas TCO
Andrew Proctor
Latha Devareddy
Robert Beitle
Reddy Yetella Ramesh
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