Extracts from Heat De-Fatted Rice Bran (HDRB) as Health-Promoting Agents (Pentapeptide)


Synthetically designed and manufactured chemicals for promoting health and preventing disease are marketed extensively as pharmaceuticals. The food industry and the general public seek alternatives that serve the same purpose as pharmaceuticals yet are derived from naturally-occurring sources; these alternatives are often referred to as nutraceuticals.

Rice bran is a by-product of milling rough rice that consists of protein, fatty acids, minerals, and fiber. Researchers at the University of Arkansas, Division of Agriculture described a novel method of separating and purifying protein from rice bran, producing high yields of Heat Defatted Rice Bran (HDRB). The researchers further isolated selected extracts from HDRB that may serve as health-promoting agents. Specific fractions of the HDRB protein extracts have inhibited the growth of various cancer cell lines in laboratory demonstrations. A specific peptide has also shown potential as an anti-Alzheimer’s treatment and anti-obesity treatment.

The HDRB extracts are candidates for use as nutraceuticals since they are:

derived from food normally consumed by humans

derived from relatively low-value rice bran

Generally Recognized As Safe (GRAS) compounds

known to inhibit the growth of certain human cancer cell lines

The technology requires further investigation in order to make serious health claims. The University of Arkansas seeks commercial partners, including food manufacturers and nutraceutical interests, to advance the technology.

For more information contact:

Nathan McKinney



Ref. 09-14, 09-40


Patent Information:
App Type Country Serial No. Patent No. File Date Issued Date Expire Date
Non-Provisional United States 12/954,285 8,575,310 11/24/2010 11/5/2013  
For Information, Contact:
Bryan Renk
Associate Director for Technology Commercialization
University of Arkansas TCO
Navam Hettiarachchy
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